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Molecular analyses showed that CO23RFLC had acquired a marked increased expression of the MDR1 gene encoding for an efflux pump protein mainly responsible for the drug-resistance, due to a mutation in the transcription factor gene MRR1 [16] whereas CO23RFK had a homozygous mutation (S645Y substitution) in the FSK1 gene, responsible for the synthesis of glucan [17]

Glutathione peroxidase values obtained in the DI treated group was significantly increased compared to DU

Mol Genet Metab 109:20814

A 2 mL reconstitution volume yields a concentration of 2,500 mcg/mL of each peptide component (5,000 mcg/mL total peptide)

10.1038/s41598-017-18278-x 77 LiT.FanG

For studies of GH-IGF axis regulation, it is a confounding variable that needs to be controlled by experimental design