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These findings suggest that the microbiome may contribute to the pathogenesis of depression through complex interactions involving microbial metabolites, neurotransmitter regulation, and immune system modulation

-Glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo

Management depends on B12 supplementation, either via high-dose oral routes or via parenteral administration

This occurs also in patients hospitalized for sepsis as lower blood GSH:GSSG ratios have been reported (Nmeth and Boda, 2001)