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GLS in the mitochondria catalyzes the initial and rate-limiting step in the breakdown of glutamine, which transforms glutamine into glutamate [33] (Fig

Data availability The datasets produced in this study are available in the following databases: Transcriptomic data: Gene Expression Omnibus (GEO) GSE281715

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Microbial sequencing results of rat feces showed that metformin, liraglutide, and their combination had beneficial effects on reversing the disorder of intestinal flora in LE-induced PCOS rats, supporting the important role of intestinal flora in the pathogenesis and treatment of PCOS

[PubMed: 39317404] Bailey CJ, Flatt PR, Conlon JM