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In the landmark STEP 1 clinical trial, patients lost an average of 14.9% of body weight over 68 weeks compared to 2.4% with placebo
This marks the world's first GLP-1 therapy delivered via a mucosal route
This resulted in ICERs of GBP 11,580 and GBP 4620 per QALY gained for oral semaglutide 14 mg versus empagliflozin 25 mg and sitagliptin 100 mg, respectively, while oral semaglutide 14 mg was considered dominant versus liraglutide 1.8 mg
The secondary structure of each peptide was estimated using the CONTIN algorithm 44,45
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