PTRS Spotlight: The Best-Positioned Bet Isnt Oral When we apply Intelligencias PTRS (Probability of Technical and Regulatory Success) framework, the most promising GLP-1adjacent asset that is not already approved is CagriSemaa fixed-dose combination of cagrilintide (amylin analogue) and semaglutide, delivered as a once-weekly subcutaneous injection
On the other hand, several investigators found that treatment with erastin could inhibit system xCT, thereby reducing extracellular cystine import for GSH synthesis and increasing the sensitivity to ferroptosis (Wang et al., 2020)
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
Chronic gut permeability is where it becomes a problem LPS crossing into the bloodstream can get past the blood-brain barrier too When it does, it activates microglia (the brains immune cells) which start breaking down the blood-brain barrier
Accessed 23 June 2025
Hepatic disease, depending on severity, can influence lamotrigine pharmacokinetics
