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GLP-1 agonists cause gastrointestinal side effects including diarrhoea and vomiting in 3045% of patients during dose titration, leading to electrolyte depletion
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doi: 10.1007/s13679-020-00379-w [DOI] [PubMed] [Google Scholar] 38
Second, decreased expression or serine phosphorylation of IRS proteins 44,45 can reduce their binding to PI3K, thereby down-regulating PI3K activation and inducing apparent IR