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8.4 1.3 pmol/mg protein

8 Challenges in clinical application Considering the enumerated benefits of GLP-1RA compared to other glucose-lowering drugs including the reduction in HbA1c and weight reduction benefits alongside decreased risk for hypoglycaemia (122) it is not cost effective if used in combination with another incretin (107)

He speculates that GLP-1 receptors in some people may have genetic differences that might influence how well the hormone binds to the receptor and activates subsequent insulin and satiety pathways

GLP-1 receptor agonists: a clinical perspective on cardiovascular effects

doi: 10.1210/en.2008-1479 [DOI] [PMC free article] [PubMed] [Google Scholar] 137.Zhao S, Kanoski SE, Yan J, Grill HJ, Hayes MR

doi:10.1016/j.arcmed.2005.01.003 30