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Mechanistic studies showed that GPX4 expression and ferrous iron were increased in 5-FU and AZ628-derived CRC persister cells, residual subcutaneous transplantation tumors, and colorectal cancer patients undergoing neoadjuvant chemoradiotherapy

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Nat Med 8:901902 Peclat TR, Agorrody G, Colman L, Kashyap S, Zeidler JD, Chini CCS, Warner GM, Thompson KL, Dalvi P, Beckedorff F et al (2024) Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity

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Kelch-like ECH-associated protein 1 (Keap1) is believed to be the major repressor of NRF2, supported by the evidence that disruption of in the mouse increased the abundance and activity of NRF2 [9]

Conversely, some research teams dose 5-amino-1MQ in the evening to maintain NAD+ elevation during overnight fasted periods, when the body naturally shifts toward fat oxidation