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and Jeremy Warshauer, MD, note that they expect the incidence and severity of irAEs to increase with the complexity and duration of combination therapies

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Furthermore, women with endometriosis have a marked increase in TNF- concentration in the granulosa cells [103, 104, 105, 106], which leads to the reduction in the size of the inner cell mass and in the proliferation of the trophoectoderm in the blastocyst, it was observed that the integration of the culture medium with LC allowed to neutralize the antiproliferative effect of TNF- and to limit DNA damage during embryo development [93]

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