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Nature Reviews Cancer , 18 (9), 533548

Chaperoning G protein-coupled receptors: From cell biology to therapeutics

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In contrast, the hippocampus of STZ-intoxicated rats showed distorted cellular morphology, misaligned, degenerated, and shrunken neurons with pyknotic and hyperchromatic nuclei, as well as vacuolated subgranular zones (Fig

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Understanding your genetic predispositions can help frame a more informed discussion with your provider about whether the additive benefit of combination therapy addresses your specific metabolic phenotype, or whether monotherapy or alternative agents might be more efficient for your genetics and lifestyle