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Makino initially proposed the concept of CSCs in 1959 (60)

Activation of ferroptosis and inhibition of myeloid suppressor cells (MDSC) combined with anti-PD-1 monoclonal antibody can greatly improve the survival rate of liver tumor mouse models and reduce liver metastasis of other tumors in situ (156)

ALAs influence on both liver function and nervous system integrity gives it a unique position within integrative medicine, offering support across several major systems

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Although zinc itself is not an antioxidant and is redox-inert, it contributes to oxidative defense through several mechanisms (178, 179)

Frequency depends on your individual health goals and B12 levels