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Dose related effects on the rat fetus (structural abnormalities and reduced body weight) occurred only at higher dosages, equal to or greater than 150 mg/kg (more than 2344-times the 10 mg clinical dose, based on AUC), which were associated with maternal toxicity

doi:10.1038/341233a0

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Moreover, oxidative stress can enhance the expression of adhesion molecules and proteases, facilitating cancer cell detachment, invasion into surrounding tissues, and entry into the bloodstream [120]

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