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GSH depletion can trigger ferroptosis, which has been exploited in cancer treatments [17], and supplementation with GSH is utilized by glutathione peroxidase 4 (GPX4) to prevent lipid peroxidation, in turn inhibiting ferroptosis

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Older adults, those with liver disease, alcohol use, malnutrition, CYP2E1 genetic variations, and users of other hepatotoxic drugs face higher depletion risk

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Two-tailed tests were performed unless testing a direction hypothesis, in which case a one-tailed test was used

Mirvetuximab soravtansine in folate receptor alpha (FR)high platinum-resistant ovarian cancer: final overall survival and post hoc sequence of therapy subgroup results from the SORAYA trial