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Nicotinamide (niacinamide), in contrast to nicotinic acid, does not contain a carboxyl radical in the 3 position on the pyridine ring and does not appear to produce flushing

doi: 10.1038/s41392-024-01881-6 51 KeatingsVMCollinsPDScottDMBarnesPJ

Patients had not plateaued

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Therefore, the abundance of SQSTM1/p62 protein could be used as a representative marker for the autophagic flux, where decrease of SQSTM1/p62 abundance is associated with autophagy induction and increased level correlates with autophagy inhibition[17] or deficiency[4,6]