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A 2016 study confirmed that when taken intranasally, compounded GSH does indeed increase brain glutathione levels

doi: 10.1016/S0021-9258(17)39180-9 93 RadaBGardinaPMyersTGLetoTL

N Engl J Med 390(13):11761185

Endothelial dysfunction, including decreased endothelial cell-dependent vasorelaxation, is increasingly proposed to be triggered by free radicals generated during auto-oxidation of homocysteine (Loscalzo, 1996)

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Zhang DL, Finn AP