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Various topical, oral, and injection-based cosmetic skin-lightening agents with different mechanisms of action are used widely across Asia, including hydroquinone, azelaic acid, kojic acid, mulberry, alpha-arbutin, beta-arbutin, glutathione, licorice root, papaya, vitamin A (e.g., retinol), vitamin B (i.e., niacinamide), and vitamin C

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The generation of OH provokes the oxidation of PUFAs and thereby initiates the cascade leading to ferroptosis

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Askeyev B, Soyama A, Miyamoto D, Hasegawa K, Matsushima H, Hara T, et al