Daily use means you interact with the vial every night, so maintaining sterile technique with each draw becomes habitual
Therefore, fatigue isnt that common compared to other side effects and typically goes away on its own
This means your health problem isnt being managed well, and that itself is unsafe
Current medical guidance treats obesity as a chronic condition, and long-term or indefinite semaglutide use is considered appropriate for patients with ongoing obesity-related health conditions
Related Reading Compounded Semaglutide 2 Semaglutide For Weight Loss 2 Glp 1 Hair Loss Plexusdx Semaglutide Tablets For Weight Loss Pricing and availability current as of June 2026
These events were generally mild to moderate in severity and included: Nausea often accompanying changes in bowel habits, particularly after dose escalation Diarrhoea loose or watery stools, sometimes with urgency Vomiting less common but reported, especially at higher doses Constipation occurring in some individuals, reflecting the variable effect on gut motility Abdominal discomfort or bloating a sensation of fullness or cramping Flatulence increased wind, which can accompany altered digestion Gastrointestinal adverse events were the most common reason for discontinuation in the Phase 2 trial, occurring in approximately 510% of participants depending on dose group