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Short non-diabetic data support remaining at 2.5 mg when weight and insulin-resistance markers are already moving and tolerability favors a hold. The label still positions 2.5 mg as the starter before 5 mg, so it is a defensible low-dose floor for selected users rather than a replacement for the 5 mg obesity-trial floor

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However, the prevailing theory, supported by a large body of anecdotal evidence from the research community, is that administering it closer to the site of injury may confer enhanced localized benefits

However, more randomized controlled trials are needed to understand how vitamin B12 impacts vision health