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This connection may be mediated by the gut microbiota and polyphenol-derived microbial metabolites, which also exert biologically relevant effects

Nature Reviews Drug Discovery , v

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Glutathione Glutathione is known as the body's most important and powerful antioxidant

Additionally, exposure to heavy metals, such as cadmium, may also contribute to the development of ME/CFS (154)

This paradoxical immune regulation underscores the need for precise modulation of necroptosis according to the treatment stage: leveraging its immune-stimulatory properties in the early stages while inhibiting its metastasis-promoting effects in the later stages [61]