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In some of such embodiments, a micronized therapeutic agent comprising micronized particles, coated micronized particles, or a combination thereof, comprises a therapeutic agent as a free base, a salt, a prodrug or any combination thereof

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[Piperaceae]) that shows many pharmacological activities, including anti-oxidant, anti-inflammatory, immune modulator, anti-cancer, and anti-asthmatic activities ( 3.1.7 Sinomenine Sinomenine is an isoquinoline-type alkaloid derived from Sinomenium acutum (Thunb.) Rehder and E.H.Wilson [Menispermaceae]