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Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

With either GLP-1 therapy or regular exercise

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However, treatment with this drug should be cautiously monitored because of adverse side-effects, such as dizziness, sleepiness, cognitive dysfunction, swelling, and weight gain