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doi: 10.1016/j.atherosclerosis.2007.05.012

( In neuronal cells, SIN markedly enhances the production of antioxidant enzymes like HO-1 and SOD, affecting both protein and mRNA levels, thereby triggering the Nrf2 pathway ( 5.4 Pharmacological effects of SIN in other diseases SIN has exhibited therapeutic efficacy in various diseases, including colitis ( and IL-6 and upregulating anti-inflammatory factors, SIN has anti-inflammatory actions that greatly improve experimental colitis ( In a CCI rat model, SIN exerts dose-dependent analgesic effects, significantly alleviating heat hyperalgesia and mechanical allodynia by increasing withdrawal reflex latency and elevating pain thresholds ( , IL-1, IL-6) and downregulation of RIP3, phosphorylated JNK, and c-Fos in the spinal cord, as well as an increased number of surviving neurons in the dorsal horn, indicating attenuation of CCI-induced neuronal death ( Beyond its role in inflammation and cancer, SIN also shows potential therapeutic efficacy in diseases such as diabetes, endotoxemia, asthma, cough, and depression

These peptides have been localized in amyloid plaques and can form oligomers and protofibrils, although A 42 is more hydrophobic and fibrillogenic (Selkoe, 2001)
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Research suggests this ratio gives strong results while keeping the safety profile high