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Off-label prescribing is legal and common in medicine, mainly when supported by clinical experience, expert guidance, or emerging evidence, says Zimmermann

Heres an example of how step therapy works: 1

This remains an emerging application and should be discussed carefully with your provider, but for patients who have plateaued with conventional rehabilitation, Synapse may offer an additional pathway

Knowing the active ingredient (semaglutide vs tirzepatide) and the manufacturer (Novo Nordisk vs Eli Lilly) usually clears it up

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Though the individual ingredients have been studied, this combination has not been well researched in large clinical trials on humans