Following structural damage and functional impairment of the muscle tissue, myofibrillar rupture and extravasation of intracellular proteins such as myoglobin, creatine kinase (CK), and lactate dehydrogenase (LDH), into the extracellular medium, trigger the local inflammatory response [47, 50,51,52]
10.1002/aur.1874 [DOI] [PMC free article] [PubMed] [Google Scholar] 56
In combination with the development of an effective antidote, this could make the use of DNP as an anti-obesity drug a realistic and safer therapeutic option
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In contrast, those treated with GLP-1 RAs showed significant reductions in the risks of mortality, MACEs, and MAKEs during a median follow-up period of 2.3 years