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Semaglutide is usually started at a low dose and increased gradually

To address the current knowledge gaps and facilitate the cost-effective use of drugs, the latest international guidelines emphasize the need to investigate treatment efficacy in different subgroups of patients 1

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While the studys design as an open-label trial warrants consideration when interpreting results, the trial supports the superiority of tirzepatides dual-action mechanism targeting both GIP and GLP-1 receptors, compared to semaglutides single GLP-1 receptor targeting approach