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Description

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The proposed pathway is restoration of pinealocyte function either by direct gene-regulatory effects on serotonin-N-acetyltransferase (AANAT) and related enzymes, or indirectly by reducing neuroendocrine stress signalling

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Determining the measured GFR (mGFR) requires measurement of an endogenous marker such as creatinine [1], or an exogenous marker such as inulin [2], iothalamate, 51 Cr-EDTA, or iohexol

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