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Four (0.62%) Ferriprox-treated subjects discontinued the drug due to increased serum ALT levels and 1 (0.16%) due to an increase in both ALT and AST

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10,11 Intramuscular use is also sometimes used to continue therapy after initial treatment via the IV route

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Li-mei Yu, [email protected] These authors have contributed equally to this work This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The difference in cytotoxicity with and without GSH highlights the on-demand release capability of the system, further supporting its potential as a smart drug delivery platform

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