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Aptamers are single-stranded DNA or RNA oligonucleotides that fold into defined three-dimensional structures, enabling high-affinity and high-specificity binding to target proteins in a manner analogous to antibodies ( Recent large-scale proteomic analysis of semaglutide therapy in individuals with overweight or obesity, with or without type 2 diabetes, demonstrated a distinct proteomic signature following treatment ( These findings support aptamer-based proteomics as a promising translational tool for identifying GLP-1RA-responsive vascular pathways, and monitoring therapeutic molecular responses

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Daniloski, Z