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Similarly, exendin-4 injection into the VMH of mice also reduced food intake and body weight, but, interestingly, decreased energy expenditureunlike liraglutide injectiondespite both acting via AMPK inhibition [99]

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For instance, while there was no direct correlation between GLP-1 therapy and increased fracture rates observed in some studies, caution is warranted when prescribing these medications to individuals with existing osteoporosis or high fracture risk

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