switching from ozempic to retatrutide vs Ozempic: Triple-Action Ozempic changed the conversation. Now

Case report: complete maternal uniparental isodisomy of chromosome 5 (iUPD(5)mat) with PCSK1 nonsense variant in an infant with recurrent diarrhea

The conversation highlights the strong bidirectional relationship between insulin resistance and thyroid dysfunction, including how each can worsen the other when left unaddressed

TRIUMPH-4: knee osteoarthritis plus obesity, the trial reported in December 2025

Elashoff M, Matveyenko AV, Gier B et al

Clinicians should be aware of these emerging reports when counseling patients, particularly those with comorbid metabolic conditions and problematic alcohol use

It is built on a guiding principle of using a low dose first