fda warning compounding semaglutide september 2025 letter hims compounded Novo Nordisk Drops & Hers: Inside the GLP-1 Crisis There's lots going on this – Diabetes advocacy group discourages use

other drugs (like injectable insulin) are effective at lowering blood sugar, but can "overshoot" their target and cause blood sugar to become too low, resulting in the dangerous condition of hypoglycemia

As of early 2026, providers should check the FDA Drug Shortage Database directly before prescribing compounded semaglutide, as shortage-based compounding authorization is subject to change

University of Zurich Verhagen J, Akdis M, Traidl-Hoffmann C, Schmid-Grendelmeier P, Hijnen D, Knol EF, Behrendt H, Blaser K, Akdis CA (2006) Absence of T-regulatory cell expression and function in atopic dermatitis skin

It also improves insulin sensitivity and metabolic flexibility in ways that complement GLP-1 mechanism

Kidney Health: Extensive research shows no negative impact on renal function in healthy users

Ozkan, B., Orhan, E., Aktas, N