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In contrast, the negatively charged AH of AtSNX1 could experience repulsion from the membrane, potentially reducing its membrane-binding efficiency and impairing subsequent membrane deformation

Nakamura T, Tu S, Akhtar MW, Sunico CR, Okamoto S, Lipton SA

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The source was

Association between the UGT1A1*28 allele, bilirubin levels and coronary heart Disease in the Framingham heart study

After refinement of the 28 PanDDA hits, 19 could be confidently assigned in the conventional electron density maps (Fig