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Inefficiency of the phagocytosis process leads to the formation of residual lipid-protein granules that cannot be degraded, known as lipofuscin, and generation of ROS occurs from the constant exposure of lipofuscin to light and oxygen tension 1

Understanding these processes is vital for developing effective therapeutic strategies to slow or halt PD progression and improve patients quality of life

Additionally, we proposed to update the cross-references in 425.605 and 425.610 to reference the entirety of 425.512