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[DOI] [PubMed] [Google Scholar] 40.Segal D.S., Kuczenski R
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Ross noted that although this study is interesting, it is significantly limited by the fact that it is only mathematical models, and does not account for real-life human behavior. Kelsey Costa, MS, RDN, a registered dietitian nutritionist and founder of Dietitian Insights, also not involved in this research, told MNT that the physiology of weight loss plateaus, as detailed in this study, suggests that weight-loss interventions like RYGB surgery, tirzepatide, and semaglutide significantly weaken the feedback control of appetite, leading to prolonged periods of weight loss before a plateau is reached. This was contrasted with the restriction of calories or macronutrients, which tend to result in plateaus within about 12 months due to the bodys feedback mechanisms that regulate energy intake and expenditure, she added
Eli Lilly did not respond to CNNs request for comment
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