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It is also possible that considerable genetic redundancy exists within enzyme classes, both in peroxide removal and in GSH oxidation

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206 Combined administration of shikonin and cisplatin increases Fe 2+ , ROS, and lipid peroxidation (LPO) levels and downregulates GPX4 in ovarian cancer cells, reducing cisplatin resistance by inducing ferroptosis

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model