Proliferation of gastric epithelial cells
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Although often presented as a broadly beneficial polyphenol, resveratrol has also been repeatedly flagged as a potentially PAINS-susceptible molecule, owing to its redox activity, metal-chelating properties, and tendency to interfere with multiple assay formats in a non-specific manner as highlighted in the Nature commentary ( Weight of evidence: Overall evidence is Low : an add-on signal on hyperactivity without core-symptom change
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Unlike retinoids or exfoliating acids, they do not typically cause irritation, peeling, or photosensitivity
Further research should assess the balance between its potential benefits and risks, particularly in patients with concurrent infections or immunocompromised states