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About tirzepatide Tirzepatide is a once-weekly dual GIP (glucose-dependent insulinotropic polypeptide) receptor and GLP-1 (glucagon-like peptide-1) receptor agonist

In normal human physiology, GLP-1 and GIP are released by the gastrointestinal tract (enteroendocrine L cells in the small intestine and colon and enteroendocrine K cells respectively) in response to nutrient intake and have half-lives of 1 to 3 min [36]

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