A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
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B12 anaemia means you either have fewer red blood cells, or there is a lower amount than normal of haemoglobin in each of your red blood cells
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Stress is also known to burn through B12