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Through several mechanisms, including direct interaction with SUR1 and membrane depolarization, intracellular calcium mobilization, and insulin granule priming modification, EPAC2 activation may promote the exocytosis of insulin granules [55, 56]

JNCI: Journal of the National Cancer Institute

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Clinical evidence indicating accelerated antidepressant response, improved cognition, enhanced sleep architecture, and reduced biomarkers of neuronal injury in elderly and medically comorbid populations underscores its relevance in late-life depression and depression associated with cognitive or vascular dysfunction (96)

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