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Lack of immunological fitness during fasting in metabolically challenged animals

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In the Phase III MARCH trial, which enrolled 93 patients across several different genetic subtypes of PFIC, Livmarli significantly improved pruritus symptoms in treated patients, as well as concentrations of serum bile acids and bilirubin

These alterations are the probable result of the lengthy cellular damage induced by MTX resulting in increased levels of ROS leading to DNA injury, oxidation, and proliferation inhibition