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There have been reports of corneal clouding or edema following ocular surgery in which BSS PLUS solution was used as an irrigating solution

But 'normalizing' can feel very different depending on the starting point of the biological system in question

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Frequency: Every 1521 days

Onishi M, Yamano K, Sato M, Matsuda N, Okamoto K

Nugent SG, Kumar D, Rampton DS, Evans DF