Treating the underlying venous will not prevent the spider veins from ever coming back, but it will significantly slow their progression
Doses as high as 2 mg (2,000 g) daily by mouth or 1 mg monthly by intramuscular (IM) injection have been used to treat pernicious anemia without significant side effects (136)
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Honestly, there are compelling arguments on both sides, and the 'right' answer often depends on the specific protocol and research objectives
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For maximum benefits, should be administered weekly