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This effect may be most prominent early in treatment and can diminish over time with long-acting GLP-1 RAs

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Modulate cell signaling: GLP-1 RAs boost cAMP activity while reducing ERK and MAPK pathways, which are often overactive in cancer

A clinician evaluates whether any combination is appropriate

Semaglutide (Ozempic, Wegovy) acts on GLP-1 alone

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