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Some patients metabolize semaglutide faster or show variable appetite suppression responses based on genetic differences in receptor sensitivity and peptide signaling

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Through polar interactions with CCR8 residues Y94 2.63 , D97 2.66 and H283 7.36 , CCL1 residue K24 acts as an upper anchor on one side of the CCL1 S25-M26-Q27 triad, thereby pushing it towards the bottom of the receptor orthosteric pocket, while CCL1 residue P29, held in place through hydrophobic interactions with CCR8 residue Y184 ECL2 , acts as a hinge on the other side of the triad (Fig

doi: 10.1007/s13224-022-01654-7

Semaglutide is also sold under the brand name Wegovy for aiding weight loss in obese and overweight individuals

That's mechanism