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Monthly dosing meaningfully shifts the adherence and persistence equation in obesity, which is still underappreciated relative to efficacy alone
Under these conditions, systemic metabolism increasingly relies on lipid-derived substrates and elevated oxidative throughput
This leads to neuroinflammation, vascular occlusion, mitochondrial dysfunction, and the aggregation of pathognomonic proteins, which, in turn, trigger neurodegeneration in the cerebral cortex for AD and the substantia nigra for PD (illustrated in Fig
While liraglutide improved spatial cognition, it also reduced astrocytes and microglia activity, ameliorated amount of A levels and mitochondrial dysfunction in cortical and hippocampal CA1 and CA3 regions, and prevented neuron loss by activating cAMP/PKA pathway in brain of 5FAD mice (188, 208)
doi: 10.1210/clinem/dgz140, 74 Kaiser Family, F (2024)
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