BENEFITS Antioxidant defense studied as a primary intracellular scavenger of reactive oxygen species (ROS) Redox balance investigated for its role in maintaining the cellular GSH/GSSG ratio Detoxification research examined as a cofactor in phase II conjugation and xenobiotic clearance Cysteine delivery studied as a transport and storage form of bioavailable cysteine Cellular protection explored in models of oxidative and electrophilic stress WHAT RESEARCHERS LOOK AT GSH/GSSG ratio as a marker of cellular redox state Glutathione peroxidase and glutathione reductase enzyme activity Conjugation reactions catalyzed by glutathione S-transferases Mitochondrial glutathione pools and oxidative-stress resistance Depletion and repletion kinetics in cell-culture models
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Glutathione reduced (GSH) is therefore a sensitive and reliable endogenous marker of oxidative stress. Study details The case-control study, nested within a cohort study, evaluated 45 women at 18 months postpartum: 15 without mood disorders and 30 with mood disorders characterized by major depression and bipolar disorder