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Department of Medicine, University Medical Centre Mainz, Johannes Gutenberg University, Mainz, Germany, Mainz, Germany Background: Fib-4 was developed as a non-invasive biomarker to predict advanced fibrosis in other liver disease and was consequently adopted in nonalcoholic fatty liver disease (NAFLD) / nonalcoholic steatohepatitis (NASH) by international guidelines

This advancement allows investigation of patient-specific disease mechanisms, therapeutic responses, and drug sensitivities (49)

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