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Ligand specificity GLP-2 and GLP-1 share high sequence similarity (69.7%) and have almost identical residues in two regions: the N-terminus (first six residues in GLP-2) that penetrates into the TMD core, and the C-terminus (residues 1833) that is recognized by the ECD and ECL1 of the receptor

These cells are responsible for producing and maintaining the myelin sheath of nerve cells so the GLP-1R agonists, like NLY01, would target mature oligodendrocytes

10mg offers ~15% better per-mg pricing but requires more careful planning

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The tirzepatide sublingual dosage chart shows typical escalation patterns for the compounded sublingual form

J Am Acad Child Adolesc Psychiatry