More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]
We may also see greater impacts from these therapies within their current indications (in line with our optimistic scenario) if newer versions prove to be more cost-effective than expected and/or deliver enhanced clinical performance
423 Pharmacological and herbal interventions Although lifestyle interventions can alleviate the symptoms of UC patients in the early stage, symptoms in the later stage cannot be treated by simple lifestyle interventions alone
doi: 10.1016/j.soard.2014.12.027 116
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