TRIUMPH-1: #retatrutide topline data Phase 3, n=2,339, 80 wk, obesity without diabetes (efficacy estimand): 12 mg: -28.3% body weight (-31.9 kg) 9 mg: -25.9% | 4 mg: -19.0% | Placebo: -2.2% 30% weight loss: 45.3% vs 0.5% 104-wk extension (BMI 35, n=532), 12 mg MTD: -30.3% Cross-trial context (obesity, no diabetes): STEP-1 SEMA 2.4 mg, 68 wk: -14.9% SURMOUNT-1 TZP 15 mg, 72 wk: -20.9% TRIUMPH-1 RETA 12 mg, 80 wk: -28.3% But: Topline press release
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Sample size calculation The sample size calculation was based on previous research examining the association between levels of glutathione and motivation (17), and the performance of the relevant population in the MIFT (6, 16)
This study revealed that oligodendrocyte cell death via controlled necrosis, termed necroptosis, is a feature of demyelination in multiple sclerosis
Author Contributions Conceived and designed the experiments: GBW NL JL
As we age, energy starts declining